Postural Changes in Lung Volumes in Obesity

Overview

Postural changes are known to affect normal lung volumes. A reduction in sitting to supine functional residual capacity (FRC) is well-described in non-obese subjects adopting a supine position. However, postural changes in lung volumes in the obese require further exploration. We aimed to longitudinally address the effects of weight loss on postural changes in lung volumes and pulmonary function, in obesity. We tested the hypothesis that supine reduction in FRC would be absent in morbid obesity and recovered upon weight loss.

Full Title of Study: “Effect of Weight Loss on Postural Changes in Pulmonary Function : a Longitudinal Study in Morbidly Obese to Obese Subjects Following Gastroplasty”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 2008

Interventions

  • Other: Postural change in lung volumes: sitting to Supine
    • Pulmonary function and arterial blood gases were assessed both prior to and after weight loss as part of pre-operative and 12-month follow-up evaluations. Pulmonary function tests were performed both in the sitting and then in the supine position.

Arms, Groups and Cohorts

  • Morbidly obese
    • Consecutive morbidly obese adults (BMI over or equal to 40 kg/m2) scheduled for bariatric surgery were prospectively recruited.Subjects with respiratory and cardiac history (asthma, Chronic obstructive pulmonary disease, heart failure) were excluded.

Clinical Trial Outcome Measures

Primary Measures

  • functional residual capacity
    • Time Frame: baseline and one year after bariatric surgery

Secondary Measures

  • lung volumes and flows
    • Time Frame: at baseline and after bariatric surgery

Participating in This Clinical Trial

Inclusion Criteria

  • subjects scheduled for bariatric surgery (BMI over or equal to 40 kg/m2) Exclusion Criteria:

  • Subjects with respiratory and cardiac history (asthma, COPD, heart failure) were excluded.

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Association pour la Formation du Personnel à la Medecine d’Urgence
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Mustapha Sebbane, MD, PhD, Principal Investigator, Montpellier University Hospital

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