T2 Weighted Imaging of the Liver With Fast Spin Echo MRI

Overview

The purpose of this study is to test two new MRI (magnetic resonance imaging) sequences to see how they compare to previously used imaging sequences as they may improve the quality of abdominal MRI.

Full Title of Study: “Enhancement of T2 Weighted Imaging of the Liver With Fast Spin Echo Magnetic Resonance Imaging (MRI).”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: Single (Investigator)
  • Study Primary Completion Date: June 2016

Detailed Description

– Approximately 50 patients undergoing routine liver MRI in our practice imaged with one of our 4 clinical scanners will undergo our standard liver MRI protocol with the addition of 2 breath-hold sequences (FSE Flex and eSSFSE) only increasing the scan time by approximately 3 minutes. – Data will be retrieved from examinations that have been performed from the patient's electronic imaging file stored in our picture archiving and communication system (PACS). – Images will be completely anonymized. No patient identifiers will be available on the images during the analysis. – Analyses will include the visual assessment of image quality, presence and severity of imaging artifact and other non-invasive imaging outcomes performed by radiologists blinded to patient information and the type of sequence performed. Data will be presented in a Likert type scale (1=poor, 2=suboptimal, 3=average, 4=above average and 5=excellent) and imaging parameters will be compared using the Wilcoxon sign rank test.

Interventions

  • Device: MRI examinations
    • Consented patients will be required to stay in the MRI scanner to complete the 2 additional sequences once their standard exam is completed.

Arms, Groups and Cohorts

  • Other: Imaging- MRI examinations
    • Liver MRI imaging will be performed on 50 patients.

Clinical Trial Outcome Measures

Primary Measures

  • The number of abdominal MRI scans deemed improved quality
    • Time Frame: Regular scan time with one of 4 clinical scanners plus 3 additional minutes
    • Data is presented in a Likert type scale (1=poor, 2=suboptimal, 3=average, 4=above average and 5=excellent) and imaging parameters are compared using the Wilcoxon sign rank test.

Secondary Measures

  • The number of MRI scans that display severity of imaging artifact
    • Time Frame: Regular scan time with one of 4 clinical scanners plus 3 additional minutes
    • Data is presented in a Likert type scale (1=poor, 2=suboptimal, 3=average, 4=above average and 5=excellent) and imaging parameters are compared using the Wilcoxon sign rank test.

Participating in This Clinical Trial

Inclusion Criteria

  • Patients undergoing routine liver MRI imaged with one of our 4 clinical scanners (MR 750W, General Electric, Milwaukee WI) Exclusion Criteria:

  • Patients not undergoing routine liver MRI

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Ottawa Hospital Research Institute
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Nick Schieda, MD, Principal Investigator, OHRI

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