Visceral Leishmaniasis and Malnutrition in Amhara Regional State, Ethiopia

Overview

The project Visceral Leishmaniasis and Malnutrition is a cohort study that aimed to assess the association between malnutrition and visceral leishmaniasis (VL). It was conducted in Libo Kemkem and Fogera districts of the Amhara Regional State in Ethiopia. Clinical, anthropometric, biochemical, immunological, parasitological and sociodemographic data of school age children from VL high prevalence communities were collected in December 2009, May 2010 and February 2011.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2009

Arms, Groups and Cohorts

  • Malnourished
    • Children with either height for age z score or body mass index for age z score below 2 standard deviations according to the World Health Organization Growth Standards for children younger than 5 years and the 2007 WHO Growth Reference for children of 5 years or older.
  • Not malnourished
    • Children with either height for age z score or body mass index for age z score equal or higher than 2 standard deviations according to the World Health Organization Growth Standards for children younger than 5 years and the 2007 WHO Growth Reference for children of 5 years or older.

Clinical Trial Outcome Measures

Primary Measures

  • visceral leishmaniasis disease
    • Time Frame: December 2009, May 2010 and February 2011 (up to 14 months)

Secondary Measures

  • visceral leishmaniasis infection
    • Time Frame: December 2009, May 2010 and February 2011 (up to 14 months)

Participating in This Clinical Trial

Inclusion Criteria

  • Reported age between 4 and 15 years of age – Currently living in the selected household Exclusion Criteria:

  • To be ill of visceral leishmaniasis at the time of the survey – To be positive to visceral leishmaniasis infection tests at the time of the first survey – To be under treatment for visceral leishmaniasis at the time of the survey – To be extremely ill of any other condition

Gender Eligibility: All

Minimum Age: 4 Years

Maximum Age: 15 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Instituto de Salud Carlos III
  • Collaborator
    • UBS Optimus Foundation
  • Provider of Information About this Clinical Study
    • Principal Investigator: Estefania Custodio, Researcher – Instituto de Salud Carlos III
  • Overall Official(s)
    • Estefania D Custodio, PhD, Study Chair, Instituto de Salud Carlos III

Citations Reporting on Results

Lopez-Perea N, Sordo L, Gadisa E, Cruz I, Hailu T, Moreno J, Aseffa A, Canavate C, Custodio E. Knowledge, attitudes and practices related to visceral leishmaniasis in rural communities of Amhara State: a longitudinal study in northwest Ethiopia. PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2799. doi: 10.1371/journal.pntd.0002799. eCollection 2014 Apr.

Custodio E, Gadisa E, Sordo L, Cruz I, Moreno J, Nieto J, Chicharro C, Aseffa A, Abraham Z, Hailu T, Canavate C. Factors associated with Leishmania asymptomatic infection: results from a cross-sectional survey in highland northern Ethiopia. PLoS Negl Trop Dis. 2012;6(9):e1813. doi: 10.1371/journal.pntd.0001813. Epub 2012 Sep 27.

Sordo L, Gadisa E, Custodio E, Cruz I, Simon F, Abraham Z, Moreno J, Aseffa A, Tsegaye H, Nieto J, Chicharro C, Canavate C. Low prevalence of Leishmania infection in post-epidemic areas of Libo Kemkem, Ethiopia. Am J Trop Med Hyg. 2012 Jun;86(6):955-8. doi: 10.4269/ajtmh.2012.11-0436.

Custodio E, Descalzo MA, Roche J, Molina L, Sanchez I, Lwanga M, Torres AM, Fernandez-Zincke E, Bernis C, Villamor E, Baylin A. The economic and nutrition transition in Equatorial Guinea coincided with a double burden of over- and under nutrition. Econ Hum Biol. 2010 Mar;8(1):80-7. doi: 10.1016/j.ehb.2009.10.001. Epub 2009 Oct 31.

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