The Effect of Coleus Forskohlii Extract on the Risk Factors of Metabolic Syndrome

Overview

Coleus forskohlii extract contains the bioactive compound, forskolin. Preliminary studies have shown that forskolin can increase fat metabolism thus reduce fat accumulation in both animals and humans. It has been suggested that forskolin may also suppress appetite thus reduce energy intake and results in weight loss. This study will evaluate the appetite suppressant properties of Coleus forskohlii extract. In addition the effect on central obesity and risk factors of metabolic syndrome will also be investigated.

Full Title of Study: “Investigation of Appetite Suppressant Properties Associated With Coleus Forskohlii in Overweight and Obese Individuals”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: May 2015

Interventions

  • Dietary Supplement: Coleus forskohlii extract
    • Ingestion of 250 mg Coleus forskohlii extract capsule twice a day for 12 weeks
  • Other: Placebo
    • Ingestion of 250 mg placebo capsule twice a day for 12 weeks

Arms, Groups and Cohorts

  • Experimental: Coleus forskohlii extract
    • Ingestion of 250 mg capsle (Coleus forskohlii extract) twice a day for 12 weeks
  • Placebo Comparator: Placebo
    • Ingestion of 250 mg capsule (placebo) twice a day for 12 weeks

Clinical Trial Outcome Measures

Primary Measures

  • changes in appetite will be assessed using visual analogue scale; blood hormone levels will also be measured using commercial kits.
    • Time Frame: Baseline and 12 weeks

Secondary Measures

  • reduction in central obesity – waist circumference will be measured on fortnight basis
    • Time Frame: 12 weeks

Participating in This Clinical Trial

Inclusion Criteria

  • Both Australian males and females, age 20-60 years, Overweight or obese (BMI >25), waist circumference of > 94 cm (male), waist circumference of >80 cm (female) Exclusion Criteria:

  • Cigarette smoker, hypertension, all types of heart, liver and kidney disease, pregnancy, lactating, Type 1 diabetes and weight loss medication.

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Olive Lifesciences Pvt Ltd
  • Collaborator
    • College of Health and Biomedicine, Victoria University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Dr. Xiao Su, +61399192318, xiao.su@vu.edu.au

References

obesity

Shivaprasad HN, Gopalakrishna S, Mariyanna B, Thekkoot M, Reddy R, Tippeswamy BS. Effect of Coleus forskohlii extract on cafeteria diet-induced obesity in rats. Pharmacognosy Res. 2014 Jan;6(1):42-5. doi: 10.4103/0974-8490.122916.

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