S. Aureus Colonization in Atopic Dermatitis

Overview

The purpose of this study is to characterize the bacterial strains that colonize children with atopic dermatitis. The investigators hypothesize that rectal cultures will be more sensitive than anterior nares cultures for detecting S. aureus colonization, and that strains of S. aureus colonizing patients with atopic dermatitis will be resistant to commonly used topical antibiotic ointments.

Full Title of Study: “Staphylococcus Aureus Colonization in Atopic Dermatitis”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: December 2016

Detailed Description

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritis and eczematous lesions with a worldwide prevalence of 15-20%. The burden of disease is highest in the most developed nations and predominantly affects children, with 50% of cases arising in the first year of life, and most others arising in the first 5 years. There is a well-known increased susceptibility to skin infection with S. aureus in patients with AD, and such infections are associated with clinical deterioration. While it is routine to evaluate for S. aureus colonization in the anterior nares, there is recent evidence suggesting that rectal colonization may be more significant. The significance of colonization site has not been evaluated in the AD population. Additionally, while topical antibiotics are a mainstay of treatment in AD, there is no routine data on the resistance to these agents. Our aim is to characterize the S. aureus colonization patterns in children with AD, including site of colonization and antibiotic resistance. We will analyze routinely-collected skin culture specimens from children with AD seen at our center and determine antibiotic susceptibility profiles. The significance of colonization site will be analyzed.

Clinical Trial Outcome Measures

Primary Measures

  • Difference in rectal and nasal S. aureus colonization rates in a population of children with atopic dermatitis
    • Time Frame: Up to 3 years

Secondary Measures

  • Rates of resistance to commonly used topical antibiotic ointments in strains of S. aureus that colonize a population of children with atopic dermatitis
    • Time Frame: Up to 20 years

Participating in This Clinical Trial

Inclusion Criteria

  • subjects with a diagnosis of atopic dermatitis seen by the Columbia University Medical Center department of dermatology – subjects ages 0 to 18 years Exclusion Criteria:

  • those patients in which a definitive diagnosis of AD cannot be made – subjects over the age of 18 years old – subjects with evidence of acute systemic illness – subjects currently taking systemic antibiotics – subjects with viral or fungal skin infection – any individual who declines participation

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: 18 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Columbia University
  • Collaborator
    • Society for Pediatric Dermatology
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Christine T Lauren, MD, Principal Investigator, Columbia University

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