Effect of Low-calorie Diet on Serum Lipids, Adipokines, Insulin Resistance and Also Body Composition in Women With Metabolic Syndrome
Overview
The purpose of this study is to evaluate the effect of a hypocaloric diet on biomarkers associated with insulin resistance, metabolic profile and body composition in women with Metabolic Syndrome.
Full Title of Study: “Effect of Hypocaloric Diet on Biomarkers of Metabolic Profile, Insulin Resistance and Body Composition in Women With Metabolic Syndrome”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: N/A
- Intervention Model: Single Group Assignment
- Primary Purpose: Treatment
- Masking: None (Open Label)
- Study Primary Completion Date: February 2010
Interventions
- Other: Low-calorie diet
Arms, Groups and Cohorts
- Experimental: Low-calorie diet
- The subjects were prescribed a daily energy intake 500 kcal lower than the estimated energy requirement.
Clinical Trial Outcome Measures
Primary Measures
- Weight
- Time Frame: Change from baseline at 3rd month
- Change from baseline weight (Kg) at 3rd month.
Secondary Measures
- Insulin resistance markers
- Time Frame: Change from baseline at 3rd month
- Change from baseline fasting glucose and insulin, homeostasis model assessment-insulin resistance and quantitative insulin sensitivity check index at 3rd month, samples were stored at -20 degrees.
Participating in This Clinical Trial
Inclusion Criteria
- BMI of 30-34.9 kg/m2, diagnostic of metabolic syndrome based on National Cholesterol Education Panel ATPIII (2002) Exclusion Criteria:
- Diabetes mellitus, non-treated thyroid disease, treatment with lipid-lowering drugs and glucocorticoids or weight loss treatment within the previous 3 months.
Gender Eligibility: Female
Minimum Age: 30 Years
Maximum Age: 45 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Universidade Federal do Rio de Janeiro
- Collaborator
- Rio de Janeiro State University
- Provider of Information About this Clinical Study
- Principal Investigator: Grazielle Vilas Boas Huguenin, Mrs – Universidade Federal do Rio de Janeiro
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