Effect of Low-calorie Diet on Serum Lipids, Adipokines, Insulin Resistance and Also Body Composition in Women With Metabolic Syndrome

Overview

The purpose of this study is to evaluate the effect of a hypocaloric diet on biomarkers associated with insulin resistance, metabolic profile and body composition in women with Metabolic Syndrome.

Full Title of Study: “Effect of Hypocaloric Diet on Biomarkers of Metabolic Profile, Insulin Resistance and Body Composition in Women With Metabolic Syndrome”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: February 2010

Interventions

  • Other: Low-calorie diet

Arms, Groups and Cohorts

  • Experimental: Low-calorie diet
    • The subjects were prescribed a daily energy intake 500 kcal lower than the estimated energy requirement.

Clinical Trial Outcome Measures

Primary Measures

  • Weight
    • Time Frame: Change from baseline at 3rd month
    • Change from baseline weight (Kg) at 3rd month.

Secondary Measures

  • Insulin resistance markers
    • Time Frame: Change from baseline at 3rd month
    • Change from baseline fasting glucose and insulin, homeostasis model assessment-insulin resistance and quantitative insulin sensitivity check index at 3rd month, samples were stored at -20 degrees.

Participating in This Clinical Trial

Inclusion Criteria

  • BMI of 30-34.9 kg/m2, diagnostic of metabolic syndrome based on National Cholesterol Education Panel ATPIII (2002) Exclusion Criteria:

  • Diabetes mellitus, non-treated thyroid disease, treatment with lipid-lowering drugs and glucocorticoids or weight loss treatment within the previous 3 months.

Gender Eligibility: Female

Minimum Age: 30 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Universidade Federal do Rio de Janeiro
  • Collaborator
    • Rio de Janeiro State University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Grazielle Vilas Boas Huguenin, Mrs – Universidade Federal do Rio de Janeiro

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