QT-prolongation in Psychiatric Hospitals

Overview

Observational study in 6 psychiatric hospitals in Flanders. Patients are included when a QT-prolonging drug is added to a medication profile that already contains a potential QT-prolonging drug. An ECG is taken before the administration of the new drug and a week after starting the new drug to investigate the change in duration of the QTc-interval. Risk factors for developing QT-prolongation and blood concentrations of potassium and creatinine are documented.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 2015

Interventions

  • Drug: drugs linked with QT-prolongation
    • all the drugs that are mentioned in the lists of QT-prolonging drugs of CredibleMeds (www.crediblemeds.org)

Arms, Groups and Cohorts

  • psychiatric patients treated with QT-prolonging drugs

Clinical Trial Outcome Measures

Primary Measures

  • change in QTc-interval (corrected for heart rate)
    • Time Frame: before and one week after the start of a QT-prolonging drug

Participating in This Clinical Trial

Inclusion Criteria

  • inpatient in one of the 6 participating psychiatric hospitals – QT-prolonging drug in the medication profile and the doctor prescribes another QT-prolonging drug Exclusion Criteria:

  • age < 18 year

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • KU Leuven
  • Collaborator
    • Agentschap voor Innovatie door Wetenschap en Technologie
  • Provider of Information About this Clinical Study
    • Principal Investigator: Eline Vandael, PhD-student – KU Leuven
  • Overall Official(s)
    • Eline Vandael, PhD-student, Principal Investigator, KU Leuven

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