Persistent Platelet Reactivity in Acute Coronary Syndrome

Overview

Study of persistent platelet reactivity during acute coronary syndrome. Patients are included at admission to the hospital. Platelet aggregation is evaluated by platelet function testing after blood sampling during hospitalization. No changes in treatment is planned.

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: November 2014

Detailed Description

Blood samples are performed on day 2 and 4 and collected with usual blood samples and analyzed by the laboratory. Maximal aggregation intensity and velocity are measured by light transmission aggregometry induced by arachidonic acid (AA) or adenosine diphosphate (ADP). Platelet function analyzer will be also used. No changes in treatment in response to the results is planned.

Clinical Trial Outcome Measures

Primary Measures

  • maximum aggregation intensity
    • Time Frame: day 2
    • Light transmission aggregometry following exposition to arachidonic acid 0.5mg/ml during the acute phase (day2-day 5)

Secondary Measures

  • Maximum aggregation intensity
    • Time Frame: Day 2
    • Light transmission aggregometry following exposition to adenosine diphosphate during the acute phase (day2-day 5) and during the chronic phase (day 30-day 60)
  • Maximum aggregation intensity
    • Time Frame: Chronic phase (day 30 to day 60)
    • Light transmission aggregometry following exposition to arachidonic acid 0.5mg/ml during the chronic phase (day 30-day 60)

Participating in This Clinical Trial

Inclusion Criteria

  • acute coronary syndrome with elevation in troponin

Exclusion Criteria

  • anticoagulant treatment

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Hopital Lariboisière
  • Provider of Information About this Clinical Study
    • Principal Investigator: Dr Jean-Guillaume DILLINGER, Department of Cardiology – Hopital Lariboisière
  • Overall Official(s)
    • Patrick Henry, MD-PhD, Study Director, Department of Cardiology – Lariboisiere Hospital – APHP

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