Intravesical Instillation of Hyaluronic Acid to Decrease Incidence of Urinary Tract Infection
Overview
Prospective trial which includes instillation of intravesical hyaluronic acid in an attempt to reduce the incidence of urinary tract infections in patients after orthotopic neobladder reconstruction.
Full Title of Study: “Is Intra – Neobladder Installations of Hyaluronic Acid, Effective in Reducing Neobladder Orthotropic Reconstruction Post-operative Urinary Tract Infections?”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Primary Purpose: Prevention
- Masking: None (Open Label)
- Study Primary Completion Date: March 2017
Interventions
- Drug: Hyaluronic Acid
- intravesical instillation of 40 mg of hyaluronic acid in 6 specific time points: 1,2,3 and 4 weeks postoperatively (After radical cystectomy and orthotopic neobladder reconstruction) 2 and 3 months postoperatively
Arms, Groups and Cohorts
- Experimental: hyaluronic acid
- intravesical instillation of 40 mg of hyaluronic acid at 6 specific time points: 1,2,3 and 4 weeks postoperatively 2 and 3 months postoperatively
- No Intervention: retrospective control patients
- retrospective control patients
Clinical Trial Outcome Measures
Primary Measures
- positive urinary culture
- Time Frame: 6 months
Secondary Measures
- urinary tract infection
- Time Frame: 6 months
Participating in This Clinical Trial
Inclusion Criteria
- patients undergoing radical cystectomy and orthotopic neobladder reconstruction Exclusion Criteria:
- patients <18 years and unwilling to participate in this study
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Rabin Medical Center
- Provider of Information About this Clinical Study
- Principal Investigator: Hanan Goldberg, MD – Rabin Medical Center
- Overall Official(s)
- Hanan Goldberg, MD, Principal Investigator, Rabin Medical Center
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