Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

Overview

This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP ,SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

Full Title of Study: “Pilot Study of Cough Peak Flow And Airway Clearance in Pediatric Patients With Neuromuscular Disease”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: January 1, 2021

Clinical Trial Outcome Measures

Primary Measures

  • Spontaneous cough clearance
    • Time Frame: Assessed at multiple time points over 30 minutes

Participating in This Clinical Trial

Inclusion Criteria

  • Age 6-21; able to cooperate with study procedures – Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy Exclusion Criteria:

  • Need for mechanical ventilation during the day – Recent (within 2 weeks) lower respiratory tract infection

Gender Eligibility: Male

Minimum Age: 6 Years

Maximum Age: 21 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Pittsburgh
  • Collaborator
    • Respirtech, Inc.
  • Provider of Information About this Clinical Study
    • Principal Investigator: Daniel J. Weiner, Associate Professor of Pediatrics – University of Pittsburgh

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