Assessment of Bioavailability of Phenolics From an Orange Peel Extract
Overview
In this study, the bioavailability of a specific orange peel extract is tested. The composition and morphology of the test product is altered compared to the generic product, which is used as a control. Due to intellectual property issues, more information cannot be given at this moment. Also the difference in bioavailability between a capsule and a lozenge is tested. The hypothesis is that the bioavailability of the altered extract will be improved compared to the control.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Single (Participant)
- Study Primary Completion Date: August 2013
Interventions
- Dietary Supplement: phenolics form orange peel
Arms, Groups and Cohorts
- Active Comparator: phenolics form orange peel, type 1
- 1 dose of 500 mg of phenolics from orange peel, orally ingested
- Active Comparator: phenolics from orange peel, type 2
- 1 dose of 500 mg of phenolics from orange peel, orally ingested
- Experimental: phenolics from orange peel, type 3
- 1 dose of 500 mg of phenolics from orange peel, orally ingested
Clinical Trial Outcome Measures
Primary Measures
- plasma concentrations of specific phenolics and their metabolites
- Time Frame: up to 24 hours
Secondary Measures
- urine concentrations of specific phenolics and their metabolites
- Time Frame: 24 hours
Participating in This Clinical Trial
Inclusion Criteria
- healthy adults – BMI 18.5 to 25 Exclusion Criteria:
- pregnancy – smoking – alcohol or drug abuse – use of medication – use of nutritional supplements – abnormal liver or kidney function
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 65 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Maastricht University Medical Center
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Chris Van der Grinten, PhD, Principal Investigator, Maastricht University Medical Center
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