Efficacy of Epidural Steroid for Controlling Pain After Primary TKA
Overview
The purpose of this study is to determine efficacy of epidural steroid for postoperative pain control after TKA
Full Title of Study: “Efficacy of Epidural Steroid in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Study Primary Completion Date: June 2015
Detailed Description
Epidural triamsinolone can reduce postoperative pain and longer duration of pain control after TKA
Interventions
- Drug: epidural triamsinolone
- add drugs into catheter at 48 hr after surgery
- Drug: epidural lidocaine
- add into catheter at 48 hr after surgery
Arms, Groups and Cohorts
- Active Comparator: Epidural lidocaine
- epidural lidocaine: 3 mL of 1% lidocaine with adrenaline and 3 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery
- Experimental: epidural triamsinolone
- epidural triamsinolone: 40 mg of triamsinolone (1 mL), 2.5 mL of 1% lidocaine with adrenaline and 2.5 mL of 1% lidocaine without adrenaline into epidural catheter at 48 hr after surgery
Clinical Trial Outcome Measures
Primary Measures
- post-operative pain
- Time Frame: 3 months
- measured with VAS for pain (VAS at rest and on motion)
Secondary Measures
- functional knee score
- Time Frame: 3 months
- measured with WOMAC
Participating in This Clinical Trial
Inclusion Criteria
- osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty – 50-85 years old – ASA class 1-3 Exclusion Criteria:
- unable to perform epidural anaesthesia – history of drug allergies: lidocaine, steroid – renal impairment (CrCl <30 mL/min) – liver impairment – cognitive function disorders – displacement of epidural catheter
Gender Eligibility: All
Minimum Age: 50 Years
Maximum Age: 85 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Thammasat University
- Provider of Information About this Clinical Study
- Principal Investigator: Supakit Kanitnate, orthopaedic department – Thammasat University
- Overall Official(s)
- Supakit Kanitnate, M.D., Principal Investigator, orthopaedic department
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