Effect of Exercise on Metabolic Health

Overview

One of the main objectives of this study will be to assess potential differences in important risk factors associated with Metabolic Syndrome in overweight adults who do not participate in a regular exercise program compared with overweight individuals who do exercise regularly. In addition, we will determine the effects of a single, modest session of exercise on the body's ability to control blood sugar and regulate fat metabolism in obese sedentary adults vs. obese adults who live a physically active lifestyle. Our study focuses on identifying mechanisms responsible for improved insulin action related to regular exercise and to provide novel targets for preventing and treating type 2 diabetes.

Full Title of Study: “Effect of Exercise on Novel Insulin Signaling Events in Human Muscle”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: September 17, 2016

Interventions

  • Other: Exercise
    • single session of exercise

Arms, Groups and Cohorts

  • Experimental: Exercise
  • No Intervention: Sedentary Control

Clinical Trial Outcome Measures

Primary Measures

  • Insulin Sensitivity
    • Time Frame: 2-3 hours
    • A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity. Insulin sensitivity will be calculated from the clamp data as the rate of glucose infusion during the steady state period of the clamp – divided by the plasma insulin concentration at this time (units: mg/uU/ml/min)

Secondary Measures

  • Resting Metabolic Rate
    • Time Frame: 20-30 min
  • Meal Tolerance Test
    • Time Frame: 3 hours

Participating in This Clinical Trial

Inclusion Criteria

  • Body Mass Index [BMI] = 30-45 kg/m2, fasting blood glucose concentration must be < or = to125 mg/dl, Hematocrit > or = to 34%, all women must be pre-menopausal Exclusion Criteria:

  • pregnancy or actively breastfeeding, weight instability (> or = to ± 5 lbs in the past month) evidence of cardiovascular or metabolic diseases, taking medications know to affect lipid and/or glucose metabolism.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Michigan
  • Collaborator
    • American Diabetes Association
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jeffrey F Horowitz, Associate Professor, Movement Science, School of Kinesiology – University of Michigan
  • Overall Official(s)
    • Jeffrey F Horowitz, PhD, Principal Investigator, University of Michigan

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