Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients

Overview

The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 2015

Detailed Description

The purpose of this study is to evaluate the usefulness of bathing with chlorhexidine wipe to reduce the risks of multidrug resistant bacteria acquisition and hospital-acquired bloodstream infection among ICU patients

Interventions

  • Drug: 2% chlorhexidine wipe
    • The ICU patients will be bathing with 2% chlorhexidine wipe
  • Drug: Soap
    • The ICU patients will be bathing with Soap

Arms, Groups and Cohorts

  • Placebo Comparator: Soap bathing
    • ICU patients will be bathing with soap at least once daily
  • Experimental: 2% chlorhexidine wipes
    • Use 2% chlorhexidine wipes to clean the patient at least once daily

Clinical Trial Outcome Measures

Primary Measures

  • The overall rate of Multidrug resistant bacteria acquisition at 7 days after received 2% chlorhexidine wipe bathing versus with soap bathing
    • Time Frame: 7 days after recieved 2% chlorhexidine wipes
    • 7 days after received 2% chlorhexidine wipes,the microbiology laboratory will process surveillance specimens using either standard culture-based at both nostrils, axillar, groins, rectum

Secondary Measures

  • The overall rate of hospital-acquired bloodstream infections per 1000 patient-days with chlorhexidine wipe bathing versus with soap bathing
    • Time Frame: 48 hours after recieved 2% chlorhexidine wipes

Participating in This Clinical Trial

Inclusion Criteria

  • Age > 18 years – Admission in critical care unit eg. ICU, respiratory care unit, Cardiac care unit with in 24 hours – Expected duration of critical care unit admission > 48 hours Exclusion Criteria:

  • History of chlorhexidine allergy

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 95 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Mahidol University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Adhiratha Boonyasiri, Doctor – Mahidol University
  • Overall Official(s)
    • Adhiratha Boonyasiri, MD, Principal Investigator, Mahidol University

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