Peritonitis and Loss of Residual Renal Function, Technique Failure and Mortality in Peritoneal Dialysis Patients

Overview

The primary objective is to analyze peritonitis rate and peritonitis bacteriology as risk factors for loss of residual renal function, technique failure and mortality in chronic kidney disease patients.

Secondary objectives are: To know the current rate of peritonitis in peritoneal dialysis population and to understand the bacteriological profile of peritonitis.

To know the rate and risk factors other than peritonitis involved in the loss of residual renal function.

To analyze the utility of alternative diagnostic tests, such as reagent strips, for early detection of peritonitis when traditional tests are not available.

To analyze the simultaneous measurement of serum creatinine and cystatin-C as alternative measurements of peritoneal clearance and residual renal function.

Full Title of Study: “The Role of Peritonitis in the Loss of Residual Renal Function, Technique Failure and Mortality in Peritoneal Dialysis Patients”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: January 2016

Arms, Groups and Cohorts

  • Incident peritoneal dialysis patients
    • Patients with chronic kidney disease incident to peritoneal dialysis treatment

Clinical Trial Outcome Measures

Primary Measures

  • Loss of residual renal function
    • Time Frame: 25 months
  • Technique (peritoneal dialysis) failure
    • Time Frame: 25 months
    • Shift to hemodialysis

Participating in This Clinical Trial

Inclusion Criteria

Inclusion criteria include: adult patients with signed informed consent given; there should not be selection for age, gender, primary cause of renal disease.

Exclusion Criteria

Patients will not be included if they were previously in hemodialysis or received renal transplant. Patients will also be excluded if they are on immunosuppressive therapy, have diagnosis of cancer, or are seropositive for HIV or hepatitis.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Coordinación de Investigación en Salud, Mexico
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Contact(s)
    • Ramon Paniagua, MD, PhD, +52-55-56276900, jrpaniaguas@gmail.com

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