Color Doppler Analysıs Of Uterin And Intraovarian Blood Flow Before And After Treatment Wıth Cabergoline In Hyperprolactinemic Patients

Overview

the investigators examined the hypothesis that hyperprolactinemia may alter uterin, endometrial and intraovarian blood flow and may contribute to increased infertility by another way.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: Single (Participant)
  • Study Primary Completion Date: August 2011

Interventions

  • Drug: cabergoline treatment
    • cabergoline treatment for hyperprolactinemia group

Arms, Groups and Cohorts

  • No Intervention: pretreatment group
    • doppler evaluation at pretreatment period
  • Experimental: posttreatment group
    • doppler evaluatıon in normoprolactinemia women who given cabergoline treatment

Clinical Trial Outcome Measures

Primary Measures

  • th effect of prolactin vascular flow and resistance
    • Time Frame: the effect of prolactin in vascular resistance at 2 weeks after treatment

Participating in This Clinical Trial

Inclusion Criteria

  • Women who had blood prolactin level higher than 25ng/dl Exclusion Criteria:

  • Pregnancy – Use of drugs effecting vasculature such as hormonal therapy, oral contraceptives, antihypertensives – Diseases like pelvic inflammatory disease and systemic hypertension – Women with clinically overt or treated cardiovascular disease – Concurrent illness other than hyperprolactinemia

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Istanbul Bakirkoy Maternity and Children Diseases Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Osman Aşıcıoğlu, sisli etfal teaching hospital department gynecology and obstetric – Istanbul Bakirkoy Maternity and Children Diseases Hospital
  • Overall Official(s)
    • Osman Temizkan, M.D., Principal Investigator, SİSLİ ETFAL TEACHİNG HOSPİTAL

References

Ono M, Miki N, Amano K, Kawamata T, Seki T, Makino R, Takano K, Izumi S, Okada Y, Hori T. Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. J Clin Endocrinol Metab. 2010 Jun;95(6):2672-9. doi: 10.1210/jc.2009-2605. Epub 2010 Mar 31.

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