Color Doppler Analysıs Of Uterin And Intraovarian Blood Flow Before And After Treatment Wıth Cabergoline In Hyperprolactinemic Patients
Overview
the investigators examined the hypothesis that hyperprolactinemia may alter uterin, endometrial and intraovarian blood flow and may contribute to increased infertility by another way.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Primary Purpose: Treatment
- Masking: Single (Participant)
- Study Primary Completion Date: August 2011
Interventions
- Drug: cabergoline treatment
- cabergoline treatment for hyperprolactinemia group
Arms, Groups and Cohorts
- No Intervention: pretreatment group
- doppler evaluation at pretreatment period
- Experimental: posttreatment group
- doppler evaluatıon in normoprolactinemia women who given cabergoline treatment
Clinical Trial Outcome Measures
Primary Measures
- th effect of prolactin vascular flow and resistance
- Time Frame: the effect of prolactin in vascular resistance at 2 weeks after treatment
Participating in This Clinical Trial
Inclusion Criteria
- Women who had blood prolactin level higher than 25ng/dl Exclusion Criteria:
- Pregnancy – Use of drugs effecting vasculature such as hormonal therapy, oral contraceptives, antihypertensives – Diseases like pelvic inflammatory disease and systemic hypertension – Women with clinically overt or treated cardiovascular disease – Concurrent illness other than hyperprolactinemia
Gender Eligibility: Female
Minimum Age: 18 Years
Maximum Age: 40 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital
- Provider of Information About this Clinical Study
- Principal Investigator: Osman Aşıcıoğlu, sisli etfal teaching hospital department gynecology and obstetric – Istanbul Bakirkoy Maternity and Children Diseases Hospital
- Overall Official(s)
- Osman Temizkan, M.D., Principal Investigator, SİSLİ ETFAL TEACHİNG HOSPİTAL
References
Ono M, Miki N, Amano K, Kawamata T, Seki T, Makino R, Takano K, Izumi S, Okada Y, Hori T. Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. J Clin Endocrinol Metab. 2010 Jun;95(6):2672-9. doi: 10.1210/jc.2009-2605. Epub 2010 Mar 31.
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