Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis

Overview

Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness. A reduction of the RNFL thickness has been detected in several neurodegenerative diseases, such as multiple sclerosis, CADASIL and Alzheimer's disease. Different studies have reported RNFL changes also in Parkinson's disease (PD),a common neurodegenerative disease characterized by motor dysfunctions, originally described by James Parkinson in 1817. PD is characterized by selective dopaminergic neuronal cells loss, which may correlate with RNFL thinning. Previous studies on this subject, however, reported contradicting results. Some investigations reported reductions of the RNFL thickness while others did not. In the present study, in order to determine whether RNFL thickness is reduced in PD patients, we performed a meta-analysis and systematically evaluated RNFL thickness measurements with OCT in a series of PD patients and in the healthy control groups.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: January 2014

Interventions

  • Device: Optical coherence tomography

Arms, Groups and Cohorts

  • healthy control
    • Sex- and agematched healthy subjects
  • Parkinson group
    • Patients with Parkinson’s disease

Clinical Trial Outcome Measures

Primary Measures

  • Retinal Nerve Fiber Layer Thickness
    • Time Frame: Baseline
    • Retinal nerve fiber layer thickness included average thickness (360° measurement), temporal quadrant thickness (316-45°), superior quadrant thickness (46-135°), nasal quadrant thickness (136-225°) and inferior quadrant thickness (226-315°)was measured by OCT.

Participating in This Clinical Trial

Inclusion Criteria

1. case-control studies; 2. patients with PD were compared with healthy controls; 3. all subjects underwent RNFL thickness measurement by OCT; 4. studies should provide the data of peripapillary RNFL thickness; 5. sample size ≥10 in each group. Exclusion Criteria:

1. authors did not make RNFL measurements; 2. study without healthy control group; 3. the outcome values can not be used for meta-analysis; 4. duplicated articles.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Yifan Feng
  • Collaborator
    • Wenzhou Medical University
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Yifan Feng, Eye Hospital, Wenzhou Medical College, China – Wenzhou Medical University
  • Overall Official(s)
    • Yifan Feng, PhD, Principal Investigator, Wenzhou Medical University

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