High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome

Overview

The aim is to investigate whether strength training or high intensity interval training is effective in improving insulin sensitivity, cardiovascular outcomes, body composition and reproductive outcomes in women with Polycystic Ovary Syndrome (PCOS). Few studies have examined the effect of strength training alone on insulin sensitivity, reproductive outcomes and body composition in women with PCOS. Most previous studies on aerobic exercise in PCOS have applied moderate exercise intensity.

Full Title of Study: “High Intensity Interval Training or Strength Training in Women With Polycystic Ovary Syndrome. A Randomized Controlled Trial”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Single (Outcomes Assessor)
  • Study Primary Completion Date: January 2014

Interventions

  • Behavioral: strength training
  • Behavioral: interval training

Arms, Groups and Cohorts

  • Experimental: strength training
    • The subjects will attend for supervised training three sessions per week for 10 weeks (9-12). The strength training program involves dynamic contraction at intensities of 60 – 70 % of 1 repetition maximum (RM) to improve strength and muscle hypertrophy. Each session will contain 8 exercises on the major muscle groups. Each drill consists of 10-12 repetitions (reps) x 3 sets separated by one minute rest between sets.
  • Experimental: interval training
    • High intensity interval training (HIT) three times per week. The three weekly supervised HIT sessions will include two 4×4 min interval sessions and one 10×1 min session. The HIT consist of “uphill” treadmill running/walking.
  • No Intervention: control
    • Based on the Norwegian recommendation we will encourage the control group to perform 60 minutes of physical activity at moderate to high intensity on a daily basis.

Clinical Trial Outcome Measures

Primary Measures

  • insulin resistance
    • Time Frame: 10 weeks
    • measured with the homeostatic model assessment for insulin resistance (HOMA-IR) method

Secondary Measures

  • Body composition
    • Time Frame: 10 weeks
    • Measured as body fat % on an impedance scale and waist circumference
  • Maximum oxygen uptake
    • Time Frame: 10 weeks
    • Measured during maximum effort exercise test
  • Endothelial function
    • Time Frame: 10 weeks
    • Flow mediated dilatation of the brachial artery.

Participating in This Clinical Trial

Inclusion Criteria

  • Women – Age 18-45 years old – PCOS Exclusion Criteria:

  • Regular high intensity endurance or strength training (two or more times per week of vigorous exercise). – Concurrent treatments (insulin sensitizers or drugs known to affect gonadotropin or ovulation, with a wash out period of 1 months prior to inclusion). – On-going pregnancy.

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Norwegian University of Science and Technology
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Trine Moholdt, phd, Principal Investigator, Norwegian University of Science and Technology

Citations Reporting on Results

Almenning I, Rieber-Mohn A, Lundgren KM, Shetelig Lovvik T, Garnaes KK, Moholdt T. Effects of High Intensity Interval Training and Strength Training on Metabolic, Cardiovascular and Hormonal Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Study. PLoS One. 2015 Sep 25;10(9):e0138793. doi: 10.1371/journal.pone.0138793. eCollection 2015.

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