Role of CD28null NKG2Dpos T Cells on Human Alloimmune Reactivity T Cell Population

Overview

This is an observational multi-center study to determine whether any single immune monitoring test or a combination of tests obtained in the first 6 months after renal transplantation correlates with acute rejection or graft loss in renal allograft recipients receiving commonly used immunosuppressive.

Full Title of Study: “Role of CD28null NKG2Dpos T Cells on Human Alloimmune Reactivity: An Untargeted T Cell Population” (# 859869783).”

Study Type

  • Study Type: Observational
  • Study Design
  • Study Primary Completion Date: January 2014

Clinical Trial Outcome Measures

Primary Measures

  • To document the prevalence and frequencies of CD4+ and CD8+ CD28null/NKG2Dpos T cells at the time of transplantation.
    • Time Frame: 6 months
  • To test whether CD28null/NKG2Dpos T cells have unique rapid activation properties to allogeneic HLA antigens in vitro
    • Time Frame: 6 months

Secondary Measures

  • To study the clinical correlations between the frequencies of alloreactive CD28null/NKG2Dpos T cells with kidney graft function and histopathology.
    • Time Frame: 6 months
  • To test the effects of induction therapy with rabbit anti-thymocyte globulin (ATG) vs. IL-2 receptor blocker antibodies on circulating CD28null/NKG2Dpos T cells.
    • Time Frame: 6 months

Participating in This Clinical Trial

Inclusion Criteria

  • human kidney transplant recipients – ATG or basiliximab induction therapy Exclusion Criteria:

  • induction therapy other than ATG or basiliximab

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • The Cleveland Clinic
  • Provider of Information About this Clinical Study
    • Sponsor

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