RNA Sequencing of Solid and Cystic Lesions of the Pancreas

Overview

The nature of cysts and solid masses in the pancreas can be difficult to diagnose. They may be benign, precancerous, or cancer. Current tests such as cytology (looking under a microscope) and tumor markers do not always give us the answer. The investigators are looking for genetic markers on biopsy specimens from the pancreas that will give us a better test for diagnosis. This study is only for diagnosing these lesions. The investigators are not treating any patients.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2014

Interventions

  • Procedure: pancreas biopsy
    • patients who are already having a pancreas biopsy will be invited to enroll. After obtaining enough tissue for usual medical care, we will divert some tissue for the study.

Arms, Groups and Cohorts

  • pancreas cysts and solid masses
    • patents referred for solid and cystic lesions of the pancreas who will have a biopsy for usual medical care.

Clinical Trial Outcome Measures

Primary Measures

  • Gene classifier that will classify lesions as benign or malignant with 95% certainty
    • Time Frame: 2 years

Participating in This Clinical Trial

Inclusion Criteria

  • greater than 18 years old,
  • not pregnant,
  • referred for endoscopic ultrasound,
  • have a cyst or mass of the pancreas needing diagnosis.

Exclusion Criteria

  • pregnant,
  • less than age 18,
  • no mass or cyst found.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Oregon Health and Science University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Sarah Rodriguez, physician – Oregon Health and Science University

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