Diffusion Weighted Magnetic Resonance Imaging for Preoperative Staging in Gastric Adenocarcinoma Patients

Overview

Preoperative staging for gastric adenocarcinoma is an important procedure to detect advanced disease stateS for the patients in which the surgery may be unnecessary to perform. Although there are many imaging techniques for this purpose, sensitivity and specificity of these techniques still remains to be low.Preoperative detection of peritoneal carcinomatosis and involvement of lymph nodes beyond D2 may prevent surgical procedures. Removal of the determined lymph nodes according to the type of the surgery is the accepted surgical method. However, accurate determination of malignant lymph nodes may prevent dissection of some groups of the lymph nodes. These findings may cause a new definition of gastric lymph node dissection.

Full Title of Study: “Use of Diffusion Weighted Magnetic Resonance Imaging to Stage Gastric Adenocarcinoma Patients Preoperatively”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: December 2013

Detailed Description

1. proven endoscopic diagnosis of gastric adenocarcinoma 2. for staging purposes, computed tomography for all patients 3. evaluation of benign and malignant lymph nodes according to computed tomography findings and mapping of the lymph nodes 4. to state precisely resectable patients according to computed tomography and anesthetic evaluation 5. evaluation of benign and malignant lymph nodes according to diffusion weighted magnetic resonance imaging findings and mapping of the lymph nodes 6. standard gastrectomy and D2 lymph node dissection 7. mapping of the lymph nodes after taking the specimen out 8. histopathological diagnosis of the lymph nodes and mapping 9. comparison of the results taken from computed tomography, diffusion weighted magnetic resonance imaging and histopathological analysis

Interventions

  • Procedure: diffusion weighted magnetic resonance imaging
    • for diagnostic purposes, diffusion weighted magnetic resonance imaging in all patients

Arms, Groups and Cohorts

  • Experimental: diffusion MRI
    • histopathology of lymph nodes diagnosed by diffusion weighted magnetic resonance imaging

Clinical Trial Outcome Measures

Primary Measures

  • efficacy of diffusion weighted magnetic resonance imaging to detect benign and malignant lymph nodes
    • Time Frame: one year
    • to compare the radiologic diagnosis of benign and malignant lymph nodes with histopathological diagnosis

Participating in This Clinical Trial

Inclusion Criteria

  • gastric adenocarcinoma proven by endoscopic biopsy; – application of both computed tomography and diffusion weighted magnetic resonance imaging; – standard gastrectomy and a D2 lymph node dissection; – desire to attend the study protocol Exclusion Criteria:

  • preoperative neoadjuvant therapy; – metastatic disease; – undesired reaction to attend the study protocol

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 75 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Bezmialem Vakif University
  • Provider of Information About this Clinical Study
    • Sponsor

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