Effect of High-calcium Intake on Substrate Metabolism During Exercise
Overview
A high-calcium intake can accelerate fat loss under energy-restricted diets. Part of this may be due to a shift in substrate metabolism where there is an increase in the rate of fat oxidation. However, whether high-calcium intake can influence substrate metabolism during exercise is not known. Accordingly, we aim to investigate the effect of 2 weeks of high-calcium intake on substrate metabolism during exercise.
Full Title of Study: “The Impact of a Calcium Supplementation on Lipid Metabolism During Exercise.”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Double (Participant, Investigator)
- Study Primary Completion Date: February 2013
Interventions
- Dietary Supplement: Calcium
- Milk-extracted calcium supplement will be used to modulate the calcium content of the milkshakes used.
- Dietary Supplement: Placebo
Arms, Groups and Cohorts
- Placebo Comparator: Control
- A chocolate milkshake with a normal calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 400 mg calcium per serving).
- Experimental: High-Calcium
- A chocolate milkshake with a high calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 1400 mg calcium per serving).
Clinical Trial Outcome Measures
Primary Measures
- Substrate metabolism
- Time Frame: 60 s samples every 3 min for 15 min
- Substrate metabolism will be assessed by the respiratory exchange ratio (rate of carbon dioxide production/rate of oxygen consumption) from samples of expired gas collected during the first 15 minutes of an incremental cycling test.
Secondary Measures
- Plasma non-esterified fatty acid concentrations
- Time Frame: Every 3 min for 15 min
- Non-esterified fatty acid concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test to indicate fatty acid availability.
- Plasma glycerol concentrations
- Time Frame: Every 3 min for 15 min
- Glycerol concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test as a marker of lipolysis.
Participating in This Clinical Trial
Inclusion Criteria
- Physically active (moderate-vigorous exercise >3 time per week) – Male – 18-40 yrs of age Exclusion Criteria:
- Smoker – Known Food Allergies – Metabolic disorders
Gender Eligibility: Male
Minimum Age: 18 Years
Maximum Age: 40 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Northumbria University
- Provider of Information About this Clinical Study
- Principal Investigator: Javier Gonzalez, Principal Investigator – Northumbria University
- Overall Official(s)
- Emma J Stevenson, PhD, Principal Investigator, Northumbria University
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