Effect of High-calcium Intake on Substrate Metabolism During Exercise

Overview

A high-calcium intake can accelerate fat loss under energy-restricted diets. Part of this may be due to a shift in substrate metabolism where there is an increase in the rate of fat oxidation. However, whether high-calcium intake can influence substrate metabolism during exercise is not known. Accordingly, we aim to investigate the effect of 2 weeks of high-calcium intake on substrate metabolism during exercise.

Full Title of Study: “The Impact of a Calcium Supplementation on Lipid Metabolism During Exercise.”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Basic Science
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: February 2013

Interventions

  • Dietary Supplement: Calcium
    • Milk-extracted calcium supplement will be used to modulate the calcium content of the milkshakes used.
  • Dietary Supplement: Placebo

Arms, Groups and Cohorts

  • Placebo Comparator: Control
    • A chocolate milkshake with a normal calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 400 mg calcium per serving).
  • Experimental: High-Calcium
    • A chocolate milkshake with a high calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 1400 mg calcium per serving).

Clinical Trial Outcome Measures

Primary Measures

  • Substrate metabolism
    • Time Frame: 60 s samples every 3 min for 15 min
    • Substrate metabolism will be assessed by the respiratory exchange ratio (rate of carbon dioxide production/rate of oxygen consumption) from samples of expired gas collected during the first 15 minutes of an incremental cycling test.

Secondary Measures

  • Plasma non-esterified fatty acid concentrations
    • Time Frame: Every 3 min for 15 min
    • Non-esterified fatty acid concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test to indicate fatty acid availability.
  • Plasma glycerol concentrations
    • Time Frame: Every 3 min for 15 min
    • Glycerol concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test as a marker of lipolysis.

Participating in This Clinical Trial

Inclusion Criteria

  • Physically active (moderate-vigorous exercise >3 time per week) – Male – 18-40 yrs of age Exclusion Criteria:

  • Smoker – Known Food Allergies – Metabolic disorders

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Northumbria University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Javier Gonzalez, Principal Investigator – Northumbria University
  • Overall Official(s)
    • Emma J Stevenson, PhD, Principal Investigator, Northumbria University

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