Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism
Overview
Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism
Full Title of Study: “Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Study Primary Completion Date: January 2011
Detailed Description
Analysis about 50 genes in glutamate synapse
Interventions
- Genetic: analysis of the glutamate synapse in autism
- Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
- Genetic: DNA collection
- DNA collection
- Other: Auditory evoked potentials
- auditory evoked potentials
Arms, Groups and Cohorts
- Experimental: Autism
- Analysis of the glutamate synapse in autism
- Other: Relative
- Analysis of the glutamate synapse in autism
- Other: Major control
- DNA collection
- Other: Minor control
- auditory evoked potentials
Clinical Trial Outcome Measures
Primary Measures
- screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients
- Time Frame: two years
Participating in This Clinical Trial
Inclusion Criteria
- have a Pervasive Developmental Disorder Exclusion Criteria:
- N/A
Gender Eligibility: All
Minimum Age: 2 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- University Hospital, Tours
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Frédérique BONNET-BRILHAULT, MD PHD, Study Director, University François Rabelais of TOURS
Citations Reporting on Results
Bonnet-Brilhault F, Alirol S, Blanc R, Bazaud S, Marouillat S, Thepault RA, Andres CR, Lemonnier E, Barthelemy C, Raynaud M, Toutain A, Gomot M, Laumonnier F. GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability. Mol Psychiatry. 2016 Mar;21(3):411-8. doi: 10.1038/mp.2015.75. Epub 2015 Jun 9.
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