Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse

Overview

The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).

Full Title of Study: “Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse.”

Study Type

  • Study Type: Observational
  • Study Primary Completion Date: September 2012

Detailed Description

The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus. The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.

Arms, Groups and Cohorts

  • Patients with pelvic organ prolapse
    • Patients, who were operated on because of pelvic organ prolapse.
  • Patients without pelvic organ prolapse
    • Patients, who had hysterectomy due to other reasons than pelvic organ prolapse.

Clinical Trial Outcome Measures

Primary Measures

  • The elastin content in tissue samples in patients with or without pelvic organ prolapse.
    • Time Frame: september 2012

Secondary Measures

  • The collagen content in tissue samples in women with or without pelvic organ prolapse.
    • Time Frame: September 2012

Participating in This Clinical Trial

Inclusion Criteria

  • surgery for pelvic organ prolapse – hysterectomy due to other benign reasons than pelvic organ prolapse Exclusion Criteria:

  • surgery due to malignancy

Gender Eligibility: Female

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Turku University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor

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