Subconjunctival Bevacizumab and Recurrent Pterygium

Overview

A study to research whether subconjunctival bevacizumab injection may potentially suppress neovascularization in pterygium, retarding and decreasing the size of recurrent pterygium.

Full Title of Study: “Interventional Trial of Subconjunctival Bevacizumab in Recurrent Pterygium”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 2012

Detailed Description

1. Pacients with recurrent pterygium 2. Anti-VEGF therapy -Bevacizumab

Interventions

  • Drug: Bevacizumab
    • One subconjunctival aplication of Bevacizumabe 0,5ml

Arms, Groups and Cohorts

  • Experimental: Subconjunctival Bevacizumab
    • One aplication of subconjunctival Bevacizumab 0,5 ml

Clinical Trial Outcome Measures

Primary Measures

  • Pterygium size after subconjunctival bevacizumab
    • Time Frame: 8 weeks
    • -Size of recurrent pterygium (measured in mm) after injection

Secondary Measures

  • Number of Participants with Adverse Events as a Measure of Safety and Tolerability
    • Time Frame: 8 weeks
    • -Number of patients with hyposphagma and irritative symptoms after subconjunctival injection

Participating in This Clinical Trial

Inclusion Criteria

  • Recurrent pterygium Exclusion Criteria:

  • Pregnant or lactating women – History of myocardial infarction – History of stroke

Gender Eligibility: All

Minimum Age: 40 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Instituto de Olhos de Goiania
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Larissa S Stival, MD, Study Chair, Instituto de Olhos de Goiania

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