Effect of Intravitreal Bevacizumab on Corneal Endothelium

Overview

To evaluate corneal endothelium cell change after intravitreal Bevacizumab injection

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 2013

Detailed Description

Intravitreal Bevacizumab has been used by retinal specialist in treatment many retinal diseases. Although it not approved by FDA for treatment. In many In vitro studies, its showed saftey in the eyes especially for corneal endothelium cells, that important cells to keep cornea clear. This study use Confoscan-Corneal confocal microsope to evaluate corneal endothelium before and after intravitreal Bevacizumab injection in routine retinal disease at 6 month follow up.

Clinical Trial Outcome Measures

Primary Measures

  • Corneal endothelium cell change after intravitreal Bevacizumab injection
    • Time Frame: 6 months
    • Measure the corneal endothelium cell using Confoscan4-Corneal confocal microscope in patient in retinal vascular clinic before and after treat with intravitreal Bevacizumab

Secondary Measures

  • Assess the complication after intravitreal Bevacizumab injection
    • Time Frame: 6 month

Participating in This Clinical Trial

Inclusion Criteria

  • aged between 20 and 80 years old
  • can come to regular follow up at 6 month
  • signed written consent forms
  • not have corneal scar, or glaucoma
  • history of treatment with laser or anti-VEGF therapy in 3 month prior to recruit
  • high risk in cerebrovascular and cardiovascular diseases
  • Pregnancy and breastfeeding
  • can undergo confocal microspopy

Exclusion Criteria

  • History of intraocular surgery or ocular trauma during study

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Khon Kaen University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Kasem Yospaiboon, Kasem Yospaiboon, MD – Khon Kaen University
  • Overall Contact(s)
    • Kasem Yospaiboon, MD, 66823057231, kasem_yod@hotmail.com

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