Migraine and Body Composition

Overview

This research is being done to look at the association between migraine and obesity.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: October 2015

Detailed Description

Research into the role of inflammatory markers and other obesity related proteins and chemicals may help us understand migraine and lead to new treatment.

Arms, Groups and Cohorts

  • Episodic migraineurs
    • Those with migraines >2 and < 12 times per month.
  • Chronic migraineurs
    • Those with migraines greater than 14 days per month.
  • Controls
    • Those without headaches other than occasional hangover, cold, flu headaches.

Clinical Trial Outcome Measures

Primary Measures

  • association between migraine and obesity – evaluate serum adipokine levels
    • Time Frame: 5 years
    • The first aim of the proposed research is to evaluate serum adipokine levels in a clinical cohort of obese and non-obese episodic and chronic migraineurs and examine their utility as markers of the presence or absence of migraine and their relationship to headache frequency.

Secondary Measures

  • association between migraine and obesity -evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT)
    • Time Frame: five years
    • The second aim of the proposed research is to evaluate subcutaneous adipose tissue (SAT) and its ratio to visceral adipose tissue (VAT),in the same clinical cohort of migraineurs to determine if regional adipose tissue differences exist between: (1) episodic migraineurs, (2) chronic migraineurs and (3) controls, thus contributing to the migraine-obesity relationship.

Participating in This Clinical Trial

Inclusion Criteria

  • Premenopausal women (18-55 years) – Normal weight (BMI = 18.5 – 24.9) or obese (BMI ≥ 30) – Diagnosis of episodic or chronic migraine or pain free control Exclusion Criteria:

  • Evidence of pain disorder other than migraine (e.g. irritable bowel syndrome) – Chronic conditions known to alter risk or pattern of migraine (e.g. hypothyroidism) – Illnesses that may affect adipokine levels (e.g. diabetes) – Clinically relevant abnormal glucose/cholesterol levels – Pregnant women – Potential participants who are unable to undergo MRI based on standard screening questionnaire (those with brain aneurysm or surgical clips, certain types of artificial heart valves, heart defibrillator or pacemaker, cochlear implants, eye implants, blood vessel coil, recently placed artificial joints, certain types of vascular stents, history of bullets, pellets, BBs, history of any implanted metal or device or who have worked with sheet metal in the past)

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Johns Hopkins University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Drs Barbara Peterlin, Director of Headache Research, Johns Hopkins Bayview – Johns Hopkins University
  • Overall Official(s)
    • Barbara L Peterlin, DO, Principal Investigator, Johns Hopkins University

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.