Evaluation of Hemodynamics and Amount of Blood Flowing Through the Kidneys During Liver Transplant by Measuring Some Physiological Substances in Blood and Urines

Overview

The purpose of this study is to verify any existing relationship between urinary parameters (such as excretion of sodium, chlorine, urinary partial CO2 pressure [PuCO2]) and general volemic indicators (such as PiCCO, ScvO2, O2 delivery) during liver transplant.

Full Title of Study: “Evaluation of Sodium Urinary Excretion, Chlorine Urinary Excretion, Urinary Partial CO2 Pressure as Renal Perfusion Indicators During Liver Transplant. Comparison With Other Polemic State Indicators (Such as PiCCO, ScvO2, O2 Delivery).”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: December 2015

Clinical Trial Outcome Measures

Primary Measures

  • Determination of hemodynamic indicators (PiCCO, ScvO2, O2-delivery) and three urinary analytes (sodium, chloride, CO2 partial pressure)
    • Time Frame: During the stay of the patient in the operating room (in average 8 hours) and the subsequent stay in the post-surgery intensive care unit (in average 5 days)

Participating in This Clinical Trial

Inclusion Criteria

  • surgery for liver transplantation – age 18-75 – ASA class I-III Exclusion Criteria:

  • age above 75 or under 18 – ASA class IV – pre-existing renal failure – pregnant patients – patients unable to give written consent

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 75 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Azienda Ospedaliera di Padova
  • Provider of Information About this Clinical Study
    • Principal Investigator: Dr. Paolo Feltracco, Principal Investigator – Azienda Ospedaliera di Padova
  • Overall Official(s)
    • Carlo Ori, Prof. M.D., Study Chair, Università degli Studi di Padova – Azienda Ospedaliera di Padova
    • Paolo Feltracco, M.D., Principal Investigator, Azienda Ospedaliera di Padova
    • Andrea Bortolato, M.D., Principal Investigator, Azienda Ospedaliera di Padova
  • Overall Contact(s)
    • Paolo Feltracco, M.D., +393493410225, paolofeltracco@inwind.it

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