Effect of Hyoscine and Promethazine on Labor Pain

Overview

It is always considered to shorten the duration of delivery without compromising the mother and fetus by obstetrics. Hyoscine and Promethazine are used widely in hospital and research is very limited, with conflicting results regarding the efficacy of these two drugs. So the investigators decided to compare of effect of hyoscine N-butyl bromide and Promethazine on length of active phase of the first stage of labor.

Full Title of Study: “Principal Investigator”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: March 2011

Interventions

  • Drug: Hyoscine
    • The samples were randomly allocated to inject of 20 mg of hyoscineIM in dilatation 3-5cm.
  • Drug: Promethazine
    • The samples were randomly allocated to inject of 25 mg of promethazine IM in dilatation 3-5cm.

Arms, Groups and Cohorts

  • Experimental: Promethazine
    • 25 mg of promethazine
  • Experimental: Hyoscine
    • 20 mg of hyoscine

Clinical Trial Outcome Measures

Primary Measures

  • Effect of Hyoscine and Promethazine on labor pain
    • Time Frame: up to 9 months

Participating in This Clinical Trial

Inclusion Criteria

  • 18-35 yrs, – primiparous, – having single fetus with cephalic presentation, gestational age 37-42 weeks, – having no medical diseases, – having no history of hospitalization due to psychological diseases, – having no addiction to cigarette, – having no complications during pregnancy such as hypertension, – BMI< 26 Exclusion Criteria:

  • bleeding – CPD – use of PG or Oxytocin – fetus distress

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 35 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Mashhad University of Medical Sciences
  • Provider of Information About this Clinical Study
    • Principal Investigator: Samira Ebrahimzadeh Zagami, School of Nursing & Midwifery – Mashhad University of Medical Sciences

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