Use Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty

Overview

The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.

Full Title of Study: “Use Dual-energy X-ray Absorptiometry and Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: July 2013

Interventions

  • Radiation: dual energy x-ray absorptiometry
    • before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months

Arms, Groups and Cohorts

  • severe knee OA who are indicated for total knee arthroplasty
    • the woman who are indicated for TKR and are post menopausal will be recruited in this study. We will excluded the patients who had immune disease ,previous fracture of femur and end stage of renal disease

Clinical Trial Outcome Measures

Primary Measures

  • change in bone mineral density
    • Time Frame: before the surgery and after the sugery (6month ,12month)
    • Use dual energy x-ray absorptiometry to detect to BMD at the distal femur

Participating in This Clinical Trial

Inclusion Criteria

  • severe knee osteoarthritis
  • post menopausal women

Exclusion Criteria

  • immune disease
  • end stage of renal disease who receive dialysis
  • history of fracture at ipsilateral distal femur

Gender Eligibility: Female

Minimum Age: 50 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • National Taiwan University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: National Taiwan University Hospital, Use dual-energy x-ray absorptiometry and quantative microradiography to predict the periprosthetic bone loss in distal femur after total knee arthroplasty – National Taiwan University Hospital
  • Overall Official(s)
    • ching chuan Jiang, professor, Principal Investigator, National Taiwan University Hospital
  • Overall Contact(s)
    • Ching Chuan Jiang, professor, 23123456, ccj@ntu.edu.tw

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