The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease


There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

Full Title of Study: “Endothelial Dysfunction in Patients With Polycystic Kidney Disease”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: April 2012

Detailed Description

This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD

Arms, Groups and Cohorts

  • polycystic kidney ,no hypertension
    • The study evaluated the association of serum uric acid levels with endothelial dysfunction in early ADPKD patients with normal renal function

Clinical Trial Outcome Measures

Primary Measures

  • Measurement of asymmetric dimethylarginine (ADMA) and flow mediated dilatation (FMD)
    • Time Frame: 4 months
    • ADMA,FMD and uric acid measurements were performed to determine endothelial dysfunction in ADPKD patients

Participating in This Clinical Trial

Inclusion Criteria

  • ADPKD patients with normal renal function, – Normotensive ADPKD patients Exclusion Criteria:

  • Patients with impaired kidney function, – Atherosclerotic disorders, – Diagnosis of hypertension, gout, diabetes, – Using of insulin, thiazide, allopurinol or uricosuric drugs

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • TC Erciyes University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Ismail Kocyigit, TC Erciyes University Medical School – TC Erciyes University
  • Overall Official(s)
    • Bulent Tokgoz, Professor, Study Director, Erciyes University Medical School

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