Risk Factor Analysis for Coronary Atherosclerosis Measured by MDCT
Overview
Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. Therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary MDCT in apparently healthy people.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: August 2012
Arms, Groups and Cohorts
- Healthy people
Clinical Trial Outcome Measures
Primary Measures
- relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT
- Time Frame: 3month
- to examine the correlation of serum concentration of various adipokine such as adiponectin, resistin, A-FABP with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score
Secondary Measures
- relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT
- Time Frame: 3months
- to examine the correlation of serum concentration of various hepatokines such as FGF-21, fetuin- A and selenoprotein P with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score
- the correlation of various inflammatory markers with coronary atherosclerosis
- Time Frame: 3months
Participating in This Clinical Trial
Inclusion Criteria
- Apparently healthy people who underwent medical routine check up in Korea Health Promotion Center. – age > 20 years Exclusion Criteria:
- History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) – Diabetes – Stage 2 hypertension – Severe renal or hepatic disease
Gender Eligibility: All
Minimum Age: 20 Years
Maximum Age: 80 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Korea University
- Provider of Information About this Clinical Study
- Principal Investigator: Kyung Mook Choi, Professor – Korea University
Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.