Risk Factor Analysis for Coronary Atherosclerosis Measured by MDCT

Overview

Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. Therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary MDCT in apparently healthy people.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 2012

Arms, Groups and Cohorts

  • Healthy people

Clinical Trial Outcome Measures

Primary Measures

  • relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT
    • Time Frame: 3month
    • to examine the correlation of serum concentration of various adipokine such as adiponectin, resistin, A-FABP with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score

Secondary Measures

  • relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT
    • Time Frame: 3months
    • to examine the correlation of serum concentration of various hepatokines such as FGF-21, fetuin- A and selenoprotein P with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score
  • the correlation of various inflammatory markers with coronary atherosclerosis
    • Time Frame: 3months

Participating in This Clinical Trial

Inclusion Criteria

  • Apparently healthy people who underwent medical routine check up in Korea Health Promotion Center. – age > 20 years Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) – Diabetes – Stage 2 hypertension – Severe renal or hepatic disease

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Korea University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Kyung Mook Choi, Professor – Korea University

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