The Effects of Escitalopram on Cytokines

Overview

The association of cytokines with escitalopram has not been investigated in patients with major depressive disorder (MDD). Hence, the investigators will examine this association.

Full Title of Study: “The Effects of Escitalopram on Cytokines in Depressive Patients”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: April 2013

Detailed Description

In addition to serotonin, inflammatory process has been suggested in the development of major depressive disorder (MDD) and in its associated treatment. Escitalopram is an antidepressant that has been widely used in patients with MDD because of the promising results. The association of cytokines with escitalopram has not been investigated in patients with MDD. Hence, the investigators will examine this association.

Interventions

  • Drug: Escitalopram
    • escitalopram 10 mg/d to 20 mg/d

Arms, Groups and Cohorts

  • Experimental: Escitalopram
    • Escitalopram 10 mg/d to 20 mg/d

Clinical Trial Outcome Measures

Primary Measures

  • The changes in cytokines
    • Time Frame: Week 0, Week 4
    • Hamilton Depression Rating Scale, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17A, G-CSF, GM-CSF, IFN-γ, MCP-1, MIP-1β, TNF-α

Secondary Measures

  • The changes in Hamilton Depression Rating Scale
    • Time Frame: week 0, week 4
    • Hamilton Depression Rating Scale, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17A, G-CSF, GM-CSF, IFN-γ, MCP-1, MIP-1β, TNF-α

Participating in This Clinical Trial

Inclusion Criteria

1. DSM-IV-defined Major depressive disorder, single episode 2. Age 20-65 3. Drug-naive 4. Hamilton Depression Rating Scale exceeding 14 scores Exclusion Criteria:

1. Major medical disorders 2. Substance use 3. Pregnant 4. Allergy to escitalopram

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Beitou Armed Forces Hospital, Taipei, Taiwan
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Peishen Ho, M.D., Study Chair, Beitou Armed Forces Hospital
  • Overall Contact(s)
    • Pei-Shen Ho, M.D., +886-2-28959808, luke_and_tina@yahoo.com.tw

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