Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors

Overview

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.

Full Title of Study: “DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: July 2016

Detailed Description

OBJECTIVES: – To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors. OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.

Interventions

  • Genetic: RNA analysis
  • Genetic: gene expression analysis
  • Genetic: mutation analysis
  • Genetic: reverse transcriptase-polymerase chain reaction
  • Other: laboratory biomarker analysis
  • Other: medical chart review

Clinical Trial Outcome Measures

Primary Measures

  • Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis

Participating in This Clinical Trial

DISEASE CHARACTERISTICS:

  • Fixed and frozen tissue samples from the ATBR01 B1 tissue bank and from the International Pleuropulmonary Blastoma Registry, Children's Hospital of Boston, and Massachusetts General Hospital – Tissue samples from patients diagnosed with: – Ovarian – Sertoli-Leydig cell tumor – Juvenile granulosa cell tumor – Adult granulosa cell tumor – Gynandroblastoma – Sex cord stromal tumor with annular tubules – Sex cord stromal tumor, undifferentiated – Sertoli tumor – Leydig tumor – Testicular: – Granulosa cell tumor – Sertoli tumor – Leydig tumor – Sertoli-Leydig – Undifferentiated stromal tumor PATIENT CHARACTERISTICS: – Not specified PRIOR CONCURRENT THERAPY: – Not specified

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: 120 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Children’s Oncology Group
  • Collaborator
    • National Cancer Institute (NCI)
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Dana A. Hill, MD, Principal Investigator, Children’s National Research Institute

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