Insecticidal School Uniforms for Dengue Prevention in Thailand
Overview
This is a randomised controlled trial that will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-15 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent high quality of insecticide impregnation with permethrin. A double-blind randomised cross-over trial at the school level will cover two dengue transmission seasons.
Full Title of Study: “Can Insecticide-treated School Uniforms Reduce Dengue Infections in School-aged Children in Thailand”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Prevention
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Study Primary Completion Date: June 2013
Interventions
- Other: permethrin insecticide
- commercial permethrin insecticide impregnation of clothing before transmission season
- Other: washing
- normal washing of school uniforms, without permethrin insecticide impregnation
Arms, Groups and Cohorts
- Placebo Comparator: normal school uniforms
- washing only
- Experimental: insecticide-treated school uniforms
- washing and insecticide treatment
Clinical Trial Outcome Measures
Primary Measures
- insecticide:placebo incidence rate-ratio (per 1,000 person-years) of laboratory-confirmed dengue cases in school-aged children
- Time Frame: up to 2 years
- Schools are cross-over randomised to insecticide-treated or untreated (placebo) school uniforms, and so the primary outcome is the rate-ratio of dengue fever cases in school children, compared between these two groups.
Secondary Measures
- comparison between intervention and placebo groups of number of serious skin reactions to insecticide-treated uniforms
- Time Frame: up to 2 years
Participating in This Clinical Trial
Inclusion Criteria
- pupils in participating schools Exclusion Criteria:
- skin sensitivity, exema
Gender Eligibility: All
Minimum Age: 7 Years
Maximum Age: 15 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Umeå University
- Collaborator
- European Union
- Provider of Information About this Clinical Study
- Principal Investigator: Peter Byass, Professor of Global Health – Umeå University
- Overall Official(s)
- Annelies Wilder-Smith, MD, Principal Investigator, Umeå University
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