Insecticidal School Uniforms for Dengue Prevention in Thailand

Overview

This is a randomised controlled trial that will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-15 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent high quality of insecticide impregnation with permethrin. A double-blind randomised cross-over trial at the school level will cover two dengue transmission seasons.

Full Title of Study: “Can Insecticide-treated School Uniforms Reduce Dengue Infections in School-aged Children in Thailand”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Prevention
    • Masking: Triple (Participant, Care Provider, Outcomes Assessor)
  • Study Primary Completion Date: June 2013

Interventions

  • Other: permethrin insecticide
    • commercial permethrin insecticide impregnation of clothing before transmission season
  • Other: washing
    • normal washing of school uniforms, without permethrin insecticide impregnation

Arms, Groups and Cohorts

  • Placebo Comparator: normal school uniforms
    • washing only
  • Experimental: insecticide-treated school uniforms
    • washing and insecticide treatment

Clinical Trial Outcome Measures

Primary Measures

  • insecticide:placebo incidence rate-ratio (per 1,000 person-years) of laboratory-confirmed dengue cases in school-aged children
    • Time Frame: up to 2 years
    • Schools are cross-over randomised to insecticide-treated or untreated (placebo) school uniforms, and so the primary outcome is the rate-ratio of dengue fever cases in school children, compared between these two groups.

Secondary Measures

  • comparison between intervention and placebo groups of number of serious skin reactions to insecticide-treated uniforms
    • Time Frame: up to 2 years

Participating in This Clinical Trial

Inclusion Criteria

  • pupils in participating schools Exclusion Criteria:

  • skin sensitivity, exema

Gender Eligibility: All

Minimum Age: 7 Years

Maximum Age: 15 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Umeå University
  • Collaborator
    • European Union
  • Provider of Information About this Clinical Study
    • Principal Investigator: Peter Byass, Professor of Global Health – Umeå University
  • Overall Official(s)
    • Annelies Wilder-Smith, MD, Principal Investigator, Umeå University

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