Adipokines and the Risk of Reflux Esophagitis

Overview

We aimed to risk faoctors for GERD and association between visceral obesity, plasma adipoline(leptin, adiponectin, IL-6, TNF-α)and development of reflux esophagitis in healthy Koreans.

Full Title of Study: “Adipokines and the Risk of Reflux Esophagitis : Prospective Case-control Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 2013

Arms, Groups and Cohorts

  • Reflux esophagitis
    • those with endoscopically proven reflux esophagitis
  • Normal
    • those with normal GFS finding (without definite mucosal break at Z-line)

Clinical Trial Outcome Measures

Primary Measures

  • Difference in serum adipokine levels between case and control groups
    • Time Frame: 2 month lager (after sampling)

Participating in This Clinical Trial

Inclusion Criteria

  • endoscopically proven reflux esophagitis Exclusion Criteria:

  • those with esophageal hiatal hernia, current PPI medication, upper GI operation history

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 75 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Seoul National University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Donghee Kim, Clinical Assistant Professor – Seoul National University Hospital
  • Overall Contact(s)
    • Kyung-Sang Yu, Professor, +82-2-2072-1920, ksyu@snu.ac.kr

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