Impact of Sarpogrelate in the Function of Endothelial Progenitor Cells

Overview

The purpose of this study is to evaluate the effects of Sarpogrelate in endothelial progenitor cells of patients with atherosclerosis.

Study Type

  • Study Type: Interventional
  • Study Design
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: October 2012

Detailed Description

Endothelial progenitor cells play an important role in vasculogenesis and vascular repair. Sarpogrelate, a inhibitor of HT2A, is used an an anti-platelet drug, however, a direct effect in vascular cells is supposed.

Interventions

  • Drug: Sarpogrelate
    • Sarpogrelate 300mg/day

Clinical Trial Outcome Measures

Primary Measures

  • The number and function of endothelial progenitor cells
    • Time Frame: 3 months

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with atherosclerosis

Exclusion Criteria

  • Patients with high risk of bleeding
  • Patients with pregnancy
  • Patients with allergic reaction of Salpogrelate

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Aichi Gakuin University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Keiko Naruse, Associate professor – Aichi Gakuin University

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