Effect of the Salbutamol on Mechanical Properties of Respiratory System

Overview

The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.

Full Title of Study: “Effect of the Use of Salbutamol on the Mechanical Properties of the Respiratory System of Healthy Individuals, Smokers and COPD Patients”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 2012

Detailed Description

Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.

Interventions

  • Drug: Salbutamol sulphate
    • bronchodilator test, beta2-agonist, short-acting, six hours duration, 400 micrograms.

Arms, Groups and Cohorts

  • Experimental: Salbutamol
    • Short-acting bronchodilator for use in humans released by the Ministry of Health, widely used worldwide for the treatment of chronic obstructive pulmonary disease.

Clinical Trial Outcome Measures

Primary Measures

  • Respiratory function test
    • Time Frame: two o’clock
    • Evaluation of pulmonary mechanics before and after salbutamol (short-acting bronchodilator) in healthy individuals, smokers and chronic obstructive pulmonary disease in stages: mild, moderate, severe and very severe according to GOLD criteria.

Secondary Measures

  • Salbutamol
    • Time Frame: twenty minutes
    • In the bronchodilator test will be used 400 micrograms of beta2-agonist short-acting. They will be asked to exhale slowly until they can no longer expel more air from the lungs. To place the inhaler with a spacer between the lips, pressing them well, but no bite. Shortly thereafter start to breathe through the mouth and will be released a jet of 100 micrograms of the bronchodilator. Then they will hold their breath for 10 seconds. 3 puffs are made with 1 minute interval between each application.

Participating in This Clinical Trial

Inclusion Criteria

  • healthy individuals, smokers and patients with chronic obstructive pulmonary disease. Exclusion Criteria:

  • healthy subjects: no history of smoking respiratory infection and disease respiratory – smokers and chronic obstructive pulmonary disease patients: asthma and other respiratory diseases.

Gender Eligibility: All

Minimum Age: 40 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Rio de Janeiro State University
  • Collaborator
    • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Provider of Information About this Clinical Study
    • Principal Investigator: Gerusa Maritimo da Costa, Master – Rio de Janeiro State University
  • Overall Official(s)
    • Gerusa M Costa, MSc, Principal Investigator, State University of Rio de Janeiro
    • Pedro L Melo, PhD, Study Director, Laboratory biomedical instrumentation
  • Overall Contact(s)
    • Agnaldo J Lopes, PhD, 55+(21) 98536162, phel.lop@uol.com.br

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.