Recurrence of Hepatocellular Carcinoma

Overview

analysis of the risk factors of intra-hepatic distant recurrence (IDR) of hepatocellular carcinoma within 1 year after radiofrequency ablation.

Full Title of Study: “Risk Factors for Recurrence of Hepatocellular Carcinoma After Radiofrequency Ablation”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: November 2012

Arms, Groups and Cohorts

  • Patients with recurrence
    • Hepatocellular carcinoma patients with intra-hepatic or distant recurrence of hepatocellular carcinoma within 1 year after radiofrequency ablation
  • Patients with no recurrence
    • Hepatocellular carcinoma with no intra-hepatic or distant recurrence of hepatocellular carcinoma within 1 year after radiofrequency ablation

Clinical Trial Outcome Measures

Primary Measures

  • Recurrence of hepatocellular carcinoma
    • Time Frame: 1 year

Participating in This Clinical Trial

Inclusion Criteria

1. Proved diagnosis of HCC according to AASLD practice guidelines (Bruix and Sherman, 2005). 2. Patients underwent RFA for HCC with BCLC (The Barcelona-Clinic- Liver-Cancer staging system) stage A (Bruix and Sherman, 2005) with no eligibility or ability to do transplantation or resection. 3. Patients should be followed-up for more than 12 months to exclude early recurrence i.e. recurrence within 1 year. 4. Patients with INR < 1.5 or prothrombin concentration > 50%. 5. Platelet count > 50000 cell/mm3. Exclusion Criteria:

1. Presence of extra-hepatic metastasis or gross vascular invasion. 2. Child class C patients. 3. Follow up period of less than 12 months.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Ain Shams University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Iman Fawzy Montasser, Lecturer of tropical medicine , Ain Shams university – Ain Shams University

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