Proprioceptive Postural Control and Chronic Obstructive Pulmonary Disease (COPD)

Overview

Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Increased risk of falling is reported in individuals with chronic obstructive pulmonary disease. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance. The aim of the study is to clarify whether proprioceptive postural control is impaired in individuals with chronic obstructive pulmonary disease.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: August 2012

Arms, Groups and Cohorts

  • chronic obstructive pulmonary disease
  • healthy matched controls

Clinical Trial Outcome Measures

Primary Measures

  • Proprioceptive postural control
    • Time Frame: 6 months
    • Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control.

Participating in This Clinical Trial

Inclusion Criteria individuals with chronic obstructive pulmonary disease:

  • Age: 40-80 years old – Spirometry (post-bronchodilator) based diagnosis of COPD (GOLD criteria) – Willingness to sign the informed consent Inclusion Criteria healthy controls: – Age: 40-80 years old – No COPD (spirometry based: FEV1/FVC ≥ 0.7 and FEV1 > 80%) – Willingness to sign the informed consent Exclusion Criteria:

  • History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant – One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder – Respiratory disorder other than COPD – α1-antitrypsin deficiency – Known history of significant inflammatory disease other than COPD – COPD exacerbation within 4 weeks prior to study – Lung surgery – Recent diagnosis of cancer – Therapy with oral corticosteroids in the last 6 weeks – Significant cardiovascular comorbidity

Gender Eligibility: All

Minimum Age: 40 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • KU Leuven
  • Collaborator
    • Universitaire Ziekenhuizen KU Leuven
  • Provider of Information About this Clinical Study
    • Principal Investigator: Simon Brumagne, Prof. dr. Simon Brumagne – KU Leuven
  • Overall Official(s)
    • Simon Brumagne, PhD, Principal Investigator, KU Leuven
    • Thierry Troosters, PhD, Principal Investigator, KU Leuven
    • Wim Janssens, MD, PhD, Principal Investigator, KU Leuven
    • Marc Decramer, MD, PhD, Principal Investigator, KU Leuven

References

Janssens L, Brumagne S, Polspoel K, Troosters T, McConnell A. The effect of inspiratory muscles fatigue on postural control in people with and without recurrent low back pain. Spine (Phila Pa 1976). 2010 May 1;35(10):1088-94. doi: 10.1097/BRS.0b013e3181bee5c3.

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