Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

Overview

This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: March 2008

Detailed Description

Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.

Interventions

  • Other: Overnight fast
    • Overnight fast from 21:00 h

Arms, Groups and Cohorts

  • Experimental: Fasting
    • Overnight fast
  • No Intervention: Feeding
    • Normal breakfast

Clinical Trial Outcome Measures

Primary Measures

  • Change in C-terminal telopeptide region of collagen type 1 (B-CTX) concentration from baseline
    • Time Frame: At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise
    • B-CTX is a specific marker of bone resorption. It’s circulating concentration is altered by both exercise and feeding

Secondary Measures

  • Change in parathyroid hormone (PTH) concentration from baseline
    • Time Frame: At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise
    • PTH is reported to induce both bone resorption and bone formation. It’s circulating concentration is altered by both exercise and feeding.

Participating in This Clinical Trial

Inclusion Criteria

  • history of weight bearing exercise – fasting vitamin D concentration of >30 nmol•L-1 and/or a fasting parathyroid hormone (PTH) concentration of <6.9 pmol•L-1. Exclusion Criteria:

  • smokers – suffered a bone fracture in the previous 12 months – musculoskeletal injury – condition/medication known to affect bone metabolism

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • QinetiQ Ltd
  • Collaborator
    • Ministry of Defence, United Kingdom
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Jonathan PR Scott, Ph.D, Principal Investigator, QinetiQ Ltd

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