Oral Estradiol Valerate Versus Oral Contraceptive Pill in Invitro Fertilization Patients

Overview

The recent controversy regarding the use of pill for cycle planning in GnRH antagonists IVF cycle has driven the search for new ways to plan IVF cycles in order to avoid weekends or to equally distribute the workload. Recently, mid-late luteal phase oral estrogens seem to be as good as the pill. The investigators will compare OCP vs oral estrogens to plan the initiation of IVF cycles.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: May 2012

Interventions

  • Drug: Levonorgestrel and ethinylestradiol
    • 30 microgram of ethinylestradiol plus levonorgestrel daily for 12 to 16 days
  • Drug: Estradiol valerate
    • 4mg estradiol valerate from cycle day 20 till the day before the initiation of the cycle

Arms, Groups and Cohorts

  • Active Comparator: OCP
  • Active Comparator: Oral estradiol valerate

Clinical Trial Outcome Measures

Primary Measures

  • Implantation rate
    • Time Frame: 20 days after the embryo transfer
    • number of embryonic sacs visible by ultrasound divided by the number of embryos transferred

Participating in This Clinical Trial

Inclusion Criteria

  • 1st or 2nd IVF cycle – BMI <30 kg/m2 – regular menstrual cycles – basal FSH <10IU and E2 <60pg/mL Exclusion Criteria:

  • polycystic ovaries – endometriosis – previous ovarian surgery – previous low ovarian response

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 38 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • IVI Madrid
  • Provider of Information About this Clinical Study
    • Sponsor

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