Oral Estradiol Valerate Versus Oral Contraceptive Pill in Invitro Fertilization Patients
Overview
The recent controversy regarding the use of pill for cycle planning in GnRH antagonists IVF cycle has driven the search for new ways to plan IVF cycles in order to avoid weekends or to equally distribute the workload. Recently, mid-late luteal phase oral estrogens seem to be as good as the pill. The investigators will compare OCP vs oral estrogens to plan the initiation of IVF cycles.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: None (Open Label)
- Study Primary Completion Date: May 2012
Interventions
- Drug: Levonorgestrel and ethinylestradiol
- 30 microgram of ethinylestradiol plus levonorgestrel daily for 12 to 16 days
- Drug: Estradiol valerate
- 4mg estradiol valerate from cycle day 20 till the day before the initiation of the cycle
Arms, Groups and Cohorts
- Active Comparator: OCP
- Active Comparator: Oral estradiol valerate
Clinical Trial Outcome Measures
Primary Measures
- Implantation rate
- Time Frame: 20 days after the embryo transfer
- number of embryonic sacs visible by ultrasound divided by the number of embryos transferred
Participating in This Clinical Trial
Inclusion Criteria
- 1st or 2nd IVF cycle – BMI <30 kg/m2 – regular menstrual cycles – basal FSH <10IU and E2 <60pg/mL Exclusion Criteria:
- polycystic ovaries – endometriosis – previous ovarian surgery – previous low ovarian response
Gender Eligibility: Female
Minimum Age: 18 Years
Maximum Age: 38 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- IVI Madrid
- Provider of Information About this Clinical Study
- Sponsor
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