Intelligence Changes Following Minor Surgery

Overview

Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted. In present study, the investigators examined the association between early exposure to anesthesia and surgery for minor surgery and intelligence changes in adolescence using the Wechsler Intelligence Scale for Children.

Full Title of Study: “Intelligence Performance in Adolescence After Early Exposure to Anesthesia and Minor Surgery”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 2012

Clinical Trial Outcome Measures

Primary Measures

  • Wechsler Intelligence Scale for Children
    • Time Frame: Average 5 years after surgery
    • Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.

Secondary Measures

  • Achenbach Child Behavior Checklist
    • Time Frame: Average 5 years after surgery
    • Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.

Participating in This Clinical Trial

Inclusion Criteria

1. Born from 1995 2. Male 3. Parents or guardian agree to attend this study 4. Undergone minor surgery (Repair of hypospadias, phimosiectomy, cryptorchidectomy or cryptorchidopexy and repair of inguinal hernia) 5. Children who scarify the No.1 to No.3 but no experience of any surgery. 6. Those who undergone minor surgery in Renji Hospital 4-6years ago. Exclusion Criteria:

1. Any congenital central nervous system diseases 2. Any congenital heart diseases 3. Any congenital dysgnosia 4. Birth weight less than 2kg 5. Ever been hypoxic encephalopathy when birth

Gender Eligibility: Male

Minimum Age: 6 Years

Maximum Age: 16 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • RenJi Hospital
  • Collaborator
    • Shanghai Children’s Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: diansan su, Principal Investigator – RenJi Hospital
  • Overall Official(s)
    • Diansan Su, M.D., Ph.D, Principal Investigator, RenJi Hospital

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