Functional MRI and MRA in Migraine With Aura


Patients who report that exposure to bright light or strenuous physical activity will induce migraine aura will be provoked using one or both of these methods. Followingly the patients will be examined by functional MRI. Íf the patients develop migraine headache, MR angiography will be performed as well. The primary study hypothesis is that the functional MRI signal will show features similar to those of the electrophysiological phenomenon of cortical spreading depression.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective

Participating in This Clinical Trial

Inclusion Criteria

  • Diagnosed with migraine with aura as defined by The International Classification of Headache Disorders 2 – Age between 18 and 80 years both inclusive – Reports that bright light or strenuous physical activity may trigger migraine aura Exclusion Criteria:

  • Contraindications towards exposure to photostimulation or strenuous exercise – Body weight above 130 kg – Pregnant or lactating females – Contraindications towards MRI scanning – History or clinical signs of: cardiovascular disease, psychiatric disease, substance abuse or any symptom or disease considered relevant by the examining physician.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Glostrup University Hospital, Copenhagen
  • Provider of Information About this Clinical Study
    • Jes Olesen, Danish Headache Center
  • Overall Contact(s)
    • Anders Hougaard, MD, +4538632713,

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