The purpose of this study is to determine the pharmacokinetics (PK) of xanthohumol (XN). Small amounts of xanthohumol occur naturally in hops, used to make beer, and XN is also found in beer itself. Studies in animals have shown that XN can lower blood sugar and blood lipids such as triglycerides, which can contribute to heart disease. The purpose of this study is to see how much of the XN is absorbed into the blood and how fast it leaves the body when taken by mouth. Once the PK study has been done, the investigators' long-term goal is to learn if xanthohumol can lower risk factors for heart disease and type-2 diabetes in humans.
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: April 2012
- Dietary Supplement: Xanthohumol
- PK study with one capsule of one of the three doses randomly assigned
Arms, Groups and Cohorts
- 20 mg
- Single dose 20 mg Xanthohumol
- 60 mg
- Single dose 60 mg Xanthohumol
- 180 mg
- Single dose 180 mg Xanthohumol
Clinical Trial Outcome Measures
- Levels of xanthohumol and metabolites.
- Time Frame: 6 days
- The outcome measures will be the levels of xanthohumol and its metabolites in blood and urine following a single dose of 20 mg, 60mg, or 180 mg of xanthohumol over a course of six days. These levels will be used to determine the pharmacokinetics of xanthohumol in humans.
Participating in This Clinical Trial
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 60 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- Oregon State University
- Oregon Health and Science University
- Provider of Information About this Clinical Study
- Principal Investigator: Jan Frederik Stevens, Associate Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, College of Pharmacy – Oregon State University
- Overall Official(s)
- Jan F Stevens, PhD, Principal Investigator, Oregon State University
- Jon Q Purnell, MD, Principal Investigator, Oregon Health and Science University
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