Psychological Morbidity and Facial Volume in HIV Lipodystrophy: Quantification of Treatment Outcome
Overview
The hypotheses of this study were that: 1. HIV lipodystrophy is associated with psychological morbidity relating to body image, anxiety and depression. 2. Treatment of HIV lipodystrophy using autologous fat transfer, polylactic acid or Bio-alcamid, is associated with an improvement in psychological morbidity and anatomical volume of treated areas. 3. The DI3D system is a valid and reproducible method of recording and measuring facial 3-D volume.
Full Title of Study: “Psychological Morbidity and Facial Volume in HIV Lipodystrophy:”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: July 2009
Detailed Description
as above
Arms, Groups and Cohorts
- autologous fat transfer
- patients received fat transfer for HIV lipodystrophy
- polylactic acid
- treatment with polylactic acid (PLA) for HIV lipodystrophy
- bio-alcamid
- bio-alcamid injections
Clinical Trial Outcome Measures
Primary Measures
- measurement of 3-D facial volume
- Time Frame: 2 years
- 3-D facial camera
Secondary Measures
- psychological outcome
- Time Frame: 2 years
- derriford appearance scale hospital anxiety and depression scale
Participating in This Clinical Trial
Inclusion Criteria
- HIV facial lipoatrophy – concurrent antiretrovirals Exclusion Criteria:
- known psychological disorder – skin allergies – significant medical problems precluding anaesthesia
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 70 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- NHS Lothian
- Provider of Information About this Clinical Study
- Dr Lisa Nelson, NHS Lothian
- Overall Official(s)
- Kenneth J Stewart, FRCSPlast, Principal Investigator, NHS Lothian
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