The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Overview

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: August 2010

Interventions

  • Other: Experimental knee pain
    • Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
  • Other: Non-painful control injections
    • Injection of isotonic saline into the infrapatellar fat pad

Arms, Groups and Cohorts

  • Experimental: Experimental Knee Pain
    • Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
  • Active Comparator: Control
    • non-painful injections of isotonic saline into the infrapatellar fatpad.

Clinical Trial Outcome Measures

Primary Measures

  • Isokinetic knee muscle strength
    • Time Frame: At baseline and after 8 weeks of exercise

Secondary Measures

  • One-leg chair rise
    • Time Frame: At baseline and after 8 weeks of exercise

Participating in This Clinical Trial

Inclusion Criteria

  • aged between 20 to 35 years – healthy – untrained (non-regular exercise participation [i.e. < 1 day/week]) Exclusion Criteria:

  • symptomatic musculoskeletal diseases – history of traumatic injuries to muscles, tendons or joints of the lower extremity – knee joint pain within a month prior to enrollment

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 35 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Frederiksberg University Hospital
  • Provider of Information About this Clinical Study
    • Henning Bliddal, The Parker Institute

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