Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma Patients

Overview

Prolactinoma is the most prevalent anterior hypophysis tumor. The principal treatment for this disorder is Dopamine agonist drugs including bromocriptin and Cabergoline. However, 50% of Bromocriptin treated and 17% of Cabergoline treated patients are resistant to these drugs. Curcumin is the main derivative of turmeric ,an old spice which is used frequently in Indian and Iranian cuisine. It has been proved that curcumin can reduce mammotrope cells proliferation and also intracellular hormone production. The purpose of this study is to evaluate the effect of turmeric on prolactinoma patients.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 2012

Interventions

  • Drug: Curcumin
    • Curcumin is prescribed to new cases of hyperprolactinoma

Clinical Trial Outcome Measures

Primary Measures

  • serum prolactin level
    • Time Frame: 2weeks and one month after treatment

Secondary Measures

  • change in LH,FSH and estradiol from baseline
    • Time Frame: one month ofter treatment

Participating in This Clinical Trial

Inclusion Criteria

  • hyperprolactinemia – microprolactinoma Exclusion Criteria:

  • pregnancy – macroadenoma – neurologic signs due to tumor

Gender Eligibility: Female

Minimum Age: 20 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Mashhad University of Medical Sciences
  • Provider of Information About this Clinical Study
    • Principal Investigator: Haleh Rokni Yazdi, assisstant professor – Mashhad University of Medical Sciences
  • Overall Contact(s)
    • haleh rokni, proffessore assisstant, 00981082976, roknih@mums.ac.ir

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