Relevance of Biomarkers in the Process of Weaning


The purpose of the study is to examine the relevance of biochemical markers (specific pulmonary and cardiac markers and markers of endogenous stress) in the process of weaning in patients with artificial ventilation.

Full Title of Study: “The Relevance of Biochemical Markers in the Process of Weaning”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: April 2012

Detailed Description

Artificially ventilated patients on our intensive care unit will be monitored if specific biomarkers have a relevance in risk stratification, optimizing therapy, outcome and success in the process of weaning. Therefore, consecutively, specific blood parameters will be taken at time of intubation,day 1 of weaning and extubation.

Arms, Groups and Cohorts

  • weaning patients

Clinical Trial Outcome Measures

Primary Measures

  • success of weaning
    • Time Frame: participants will be followed for the duration of hospital stay, an expected average of 30days
    • primary outcome measure is the success of weaning during hospital stay. Duration of hospital stay is estimated between 1-60days, in average 30days. Criteria is spontaneous breathing.

Secondary Measures

  • follow up
    • Time Frame: 12 months
    • Follow up is done after 12 months to check major adverse cardiac or pulmonary events (death, myocardial infarction, re-hospitalisation)

Participating in This Clinical Trial

Inclusion Criteria

  • Written informed consent
  • Able and willing to understand the protocol
  • At least 18 years or older

Exclusion Criteria

  • Not fulfilling inclusion criteria

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Heidelberg University
  • Provider of Information About this Clinical Study
    • Prof. Dr. Evangelos Giannitsis, Department of Cardiology, University of Heidelberg
  • Overall Contact(s)
    • Evangelos Giannitsis, Prof. Dr., 0049-6221-56-38686,

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