The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention.
Full Title of Study: “Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus in the Outpatient Setting: a Randomized Controlled Study”
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: None (Open Label)
- Study Primary Completion Date: April 2012
- Drug: pharmacological decolonization treatment
- Chlorhexidine gluconate 4% body scrub and 2% shampoo daily PLUS mupirocin 2%, fusidic acid 2%, or chlorhexidine gluconate 0.2% intranasally bid PLUS trimethoprim-sulfamethoxazole 160/800mg po bid or doxycycline 100mg po bid all for 7 days
- Behavioral: Education
- No pharmacological decolonization treatment but given education regarding personal hygiene and environmental cleaning
Arms, Groups and Cohorts
- Active Comparator: decolonization treatment
- topical antiseptic, intranasal antimicrobial, and oral antimicrobial that have activity against MRSA in addition to education regarding personal hygiene and environmental cleaning
- Other: education
- No decolonization treatment in addition to education regarding personal hygiene and environmental cleaning
Clinical Trial Outcome Measures
- Eradication of MRSA carriage
- Time Frame: 90 days after randomization
- Occurrence of MRSA infection
- Time Frame: Within 6 months of randomization
Participating in This Clinical Trial
- Prior MRSA infection (i.e index case)
- Identified as being colonized with MRSA on initial screen
- Are pregnant or breastfeeding.
- Have indwelling catheters.
- Received prior decolonization treatment within last 6 months of enrollment.
- Have allergy to study medication.
- Are colonized with MRSA strain resistant to study medication.
- Have active infection requiring systemic antimicrobials.
- Are household contacts to index case.
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- Joseph Kim
- Alberta Health Services
- Provider of Information About this Clinical Study
- Sponsor-Investigator: Joseph Kim, Clinical Assistant Professor – University of Calgary
- Overall Official(s)
- Thomas J Louie, MD, Principal Investigator, University of Calgary
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